Sometime after the Manhattan Incident of 2009, Meryl was appointed the field commander of Rat Patrol 01. In 2014, she became involved in a secret operation to capture Liquid Ocelot.
When she meets Snake again for the first time during the Guns Of The Patriots incident in the Middle East, she expressed her shock upon looking at Snake's more aged appearance. She was once more shocked (and infuriated) that Campbell sent him to the Middle East. In an attempt to take Liquid by force, in Eastern Europe, she became involved in a massacre that wounded her and her unit, as well as killing most of the nearby military soldiers and damaging some of the vessels.
Meryl also helped Snake infiltrate Outer Haven, and she and Johnny attempted to hold back Liquid's forces while Snake headed to GW's control room. After the incident Meryl and Johnny married, and Meryl made peace with her father, Roy Campbell.
