MGS3 Time Paradox

Because Metal Gear Solid 3: Snake Eater is a prequel to the other games in the Metal Gear Solid series, there are certain events that would damage the continuity of the Metal Gear timeline, This causes a Time Paradox.

Snake

If Naked Snake is killed, the game comes up with the traditional Game Over page displaying "SNAKE IS DEAD". After a little while (or quickly if you select Exit instead of Continue) "SNAKE IS DEAD" changes to "TIME PARADOX". This is because Naked Snake is revealed at the end of the game to be Big Boss, the genetic father of Solid Snake, Liquid Snake and Solidus Snake, and if he was to die, the events of Metal Gear Solid: Portable Ops, Metal Gear, Metal Gear 2 Solid Snake, Metal Gear Solid, Metal Gear Solid 2: Sons of Liberty and Metal Gear Solid 4: Guns of the Patriots could not take place.

Sokolov

A grenade can be thrown through the window of the room Sokolov is being held in, bringing up the Game Over page displaying "MISSION FAILED". His death compromises the Virtuous Mission, and he would not be able to complete the Shagohod.

Ocelot

Ocelot can be killed if Snake shoots his unconscious body near the end of the Virtuous Mission, bringing up the Game Over screen and the message "OCELOT IS DEAD". Like Snake, Ocelot causes a Time Paradox because of his involvement in future games. Throughout the rest of the game, he also plays a major role; he switches the Philosophers' Legacy microfilm for a fake and is responsible for the loss of Snake's right eye. Ocelot is also one of the founding members of the Patriots.

EVA

If EVA is killed, a Time Paradox is created, bringing up the message "EVA IS DEAD". Snake needs her to pilot the Wig Aircraft. She was also important in stealing the Philosophers' Legacy as the Boss used her to give it to Snake (Although this was most likely a fake).Eva also had a role in forming The Patriots. Eva has a role in the events of MGS4, going by the codename of Big Mama which turns out to be Snakes surrogate mother.