Raiden returned in 2014, and while Solid Snake was in South America, he contacted him through Codec, helping him track Naomi, also commenting that he had been helping Big Mama find the corpse of Big Boss. Raiden appeared in person in the South American Marketplace where he helped Snake and Otacon escape by fighting off the Gekko and later Vamp. He defeated Vamp once again and escaped with Snake, Otacon and Naomi.
After a dialysis and a "white blood" transfusion with the help of Dr. Madnar, he returned again to help Snake at Shadow Moses. He has a final face off with Vamp, after Snake returned him to his mortal state, on top of Metal Gear REX, with Raiden emerging the victor, finally killing Vamp once and for all. With Snake controlling REX, Raiden assisted in his escape by warding off the Gekko chasing them, eventually being caught under debris caused by the Suicide Gekko. He sets himself free from under the debris by removing his right arm.
He put himself in the way of Outer Haven, stopping its path and holding it back. Raiden was crushed under it, screaming Rose's name and remembering a conversation of how they met as well as images reuniting with her at Federal Hall during the the end of the Manhattan Incident before he loses conciousness. He was confirmed later to be alive by Otacon but was in no state to help Snake in his final mission aboard Outer Haven.
However, as Snake made his way deeper into Haven, he was saved from a group of FROGS by Raiden, who was now wielding his sword between his teeth. As he defeated several of them but was eventually overwhelmed, but as Snake and Otacon destroyed GW once again, this time along with the other three AIs, the FROGS were incapacitated and unable to kill him.
