Campbell, now working for a counter-terrorism branch of the United Nations, contacted his old friend Solid Snake, along with his partner Hal Emmerich, after he had discovered the whereabouts of the long missing Liquid Ocelot. Not content with the UN and other governments simply ignoring Liquid's attempt to plunge the world into total war, in effect aiding the economy of the 21st Century, Campbell took the matter into his own hands and hired Snake to perform an assassination. Upon reaching the Middle East, Snake met up with Meryl Campbell's daughter, who revealed to Snake that Campbell had remarried to a much younger woman and she was no longer speaking with "that womanizing piece of shit." Campbell was visibly upset when Snake divulged his daughter's opinion of him, but Campbell had to keep the secret that his marriage to Rosemary was a lie up until Raiden was done with his mission in order to protect John.
At the end of the mission, Campbell attends Meryl's wedding to Johnny Sasaki, finally making amends with her after years of deceit and not speaking. He congratulates Meryl for getting married but she ignores him. Campbell begins to walk away before Meryl pulls her Desert Eagle from her holster, holding it to Campbell's neck. She then releases the clip, forcefully telling him, "You're going to walk me down the aisle." Campbell laughs and tells Meryl that finally, they have plenty of time to get to know each other. Campbell remarks how beautiful Meryl looks, making both her and Mei Ling, Meryl's bridesmaid, break down in tears.
